![]() Outer and inner plexiform layers (OPL, IPL) contain synapses. Organization of cells and synapses in mammalian retina.Ĭellular layers (shaded) include outer and inner nuclear layers (ONL, INL) ganglion cell layer (GCL). We emphasize four select topics that have seen exciting recent advances: 1) How newborn neurons know when and where to initiate dendrite formation 2) cell-cell recognition cues in dendrite patterning 3) factors that influence dendrite growth in adulthood 4) how dendrites subdivide into functionally distinct compartments. 1) as a unique tool for linking development, anatomy, and circuit computations. The retina has been a particularly useful model, especially with the emergence of the retinal direction-selective circuit ( Fig. To this end, a wide variety of experimental model systems have been used here we focus on insights derived from mouse retina, while touching on other mammalian experimental systems. Current research seeks to understand mechanistically how these broad strategies are implemented. Together these strategies ensure that the identity, number, and functional impact of inputs are appropriate. ![]() Third, dendrites within the same cell can become molecularly distinct, such that they receive different types of synapses or filter inputs differently. Second, sampling from potential afferents is regulated by extracellular molecular cues, located in the environment or on neighboring arbors, that dictate arbor shape. Several broad developmental strategies facilitate matching of form to function: First, dendrite growth is coupled to contact and synapse formation with presynaptic afferents. Through their anatomy, connectivity, and electrical properties, dendrites help make each cell type unique.ĭuring development, dendrite growth and patterning must be tailored to the ultimate function of each cell. This is for good reason: Each of the brain’s many cell types has a distinctive dendritic pattern because each has a distinct function, and the dendrites are where functional differences arise. Probably, the first feature that comes fondly to mind is the shape of the cell’s dendrites. Ask a neuroscientist to imagine their favorite cell type (most of us have one).
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |